奥美拉唑治疗上消化道出血临床疗效观察

目的分析奥美拉唑治疗上消化道出血临床疗效。方法对我院2004年5月至2009年8月应用奥美拉唑(80 mg+8 mg/h)方案治疗48例上消化道大出血患者进行观察。结果奥美拉唑组有2例继续上消化道出血,其止血率91.67%;而对照组有8例继续上消化道出血,其止血率66.67%;经校正χ2检验,差异有统计学意义(χ2=8.65,P<0.01)。在治疗过程中,未发现不良反应。结论上消化道大出血药物止血中,迅速提高胃内pH值致关重要,pH>6.0,奥美拉唑80 mg+8 mg/h维持治疗72 h能迅速提高胃pH值,pH>6.0并能持续维持,可促进血小板聚集和纤维蛋白凝块的形成,避免血凝块过早溶解,有利于止血和预防再出血,降低输血量,降低死亡率。临床应用效果较好。

Objective To analyze the Omeprazole Sodium in treatment of upper gastrointestinal hemorrhage in the clinical efficacy.Methods To observe the therapeutic effect of Omeprazole Sodium（80 mg＋8 mg/h） cured the 48 patients with massive hemorrhage of the upper gastrointestinal tract from May,2004 to August,2009 in our hospital.Results The Omeprazole Sodium group had 2 cases of gastrointestinal rebleeding,and hemostasis rate was 91.67%.However,there were 8 cases of gastrointestinal rebleeding in the control group,and only 66.67% hemostasis rate.No adverse reactions in the treatment group.Furthermore,upon testing via calibration chi-square we can see that the Omeprazole Sodium group was superior to control group and the difference was significant（χ^2=8.65,P〈0.01）.Conclusion As with all drugs in treatment of upper gastrointestinal hemorrhage,to increase the gastric pH（pH〉6.0） rapidly is extremely important.Accepted Omeprazole Sodium（80 mg＋8 mg/h） as 72 h maintenance therapy could improve the gastric pH（pH〉6.0）rapidly,and keep steady.What is more,this method could promote platelet aggregation,form the fibrin clot,and avoid blood clots prematurely dissolved.These are conducive to stop the bleeding and prevent further bleeding.So,this method could reduce the amount of blood transfusion to reduce the mortality.Omeprazole Sodium（80 mg＋8 mg/h） has extremely good clinical results.