2HEMMI H,TAKEUCHI O,KAWAi T. A Toll-like receptor recognizes bacterial DNA[J].Nature,2000,(6813):740-745.doi:10.1038/35047123.
3LOPEZ A M,HECKER R,MUTWIRI G. Formulation with CpG ODN enhances antibody responses to an equine influenza virus vaccine[J].Vet Immunol Immunopatho1,2006,(1-2):103-110.
4MOLDOVEANU Z,LOVE-HOMAN L,HUANG W Q. CpG DNA,a novel immune enhancer for systemic and mucosal immunzation with influenza virus[J].Vaccine,1998,(11-12):1216-1224.
5SHI T,LIU W Z,GAO F. Intranasal CpG-oligodeoxynucleotide is a potent adjuvant of vaccine against Helicobacter pylori,and T helper 1 type response and interferongamma correlate with the protection[J].Helicobacter,2005,(01):71-79.doi:10.1111/j.1523-5378.2005.00293.x.
6CARPENTIER A F,AUF G,CHEN L. Implication of macrophages in tumor rejection induced by CpG-oligodeoxynucleotides without antigen[J].Clinical Cancer Research,2001,(11):3540-3543.
7BOURQUIN C,SCHREIBER S,BECK S. Immunotherapy with den- dritic cells and CpG oligonucleotides can be combined with chemotherapy without loss of efficacy in a mouse model of colon cancers[J].International Journal of Cancer,2006,(11):2790-2795.
10JAIN V V,BUSINGA T R,KITAGAKI K. Mucosal immunotherapy with CpG oligodeoxynucleotides reverses a murine model of chronic asthma induced by repeated antigen exposure[J].American Journal of Physiology-Lung Cellular and Molecular Physiology,2003,(05):1137-1146.
3KRIEG A M,YI A K, KLINMKN D M. CpG motifs in bacterial DNA trigger direct B-cell activation [ J]. Nature, 1995,374:546 - 549.
4KLINMAN D M, YI A K, BEAUCAGE S L, et al. CpG motifs present in bacterial DNA rapidly induce 1.vmplaocytes to secrete interleukin 6, interleukin 12, and interferon r[ J]. Proc Nail Acad Sci USA,1996,13:2 879 - 2 883.
5KLINMAN D M, YAMSHCHIKOV G, ISHIGATSUBO Y.Contribution of CpG motifs to the immunogenicity of DNA vaccines[J]. J Immunol, 1997,158(8) :3 635 - 3 655.
6TOKUNAGA T, YAMAMO'ID H, SIIIMAD A S, et al. Antitumor activity of deoxyribonucleic acid fraction from mycobacterium bovis BCG isolation, physicochemical characterization, and antitumor activity[J]. J Nail Cancer Inst,1984,72:955 - 962.
7CHU I1 S, TAItGONq O S, KRIEG A M, et al. CpG oligodeoxynucleotides as adjuvants that switch on T helper 1(Thl) immunity[J]. J Exp Med, 1997, 186(10): 1 623-1 631.
8沈关心 周汝麟.现代免疫学实验技术[M].武汉:湖北科学技术出版社,2002..
9沈关心 周汝麟.现代免疫学实验技术[M].湖北科学技术出版社,2002..
10Tokunaga T,Yamamoto H,Shimada S,et al.Wntitumor activity of deoxyribonucleic acid fraction from mycobacterium bovis BCG Isolation,physicochemical characterization,and antitumor activity[J].J Natl Cancer Inst,1984,72:955-962.
