Nrf2-ARE通路在自噬过程中的变化及其对肝癌细胞周期的影响

Change of the Nrf2-ARE pathway in the process of autophagy and its effect on hepatic carcinoma cell cycle

肝癌是我同常见的恶性肿瘤之一，在其发生过程中，白噬活性以及Nrf2-ARE通路的改变发挥着重要作用。Nrf2属于CNC家族，是肝癌的重要调节剂，自噬抑制后Nrf2-ARE通路活化有助于研究肝癌的发生发展。本文旨在探讨自噬与Nrf2-ARE通路的相互关系及其对肝癌的影响。

Hepatic carcinoma is one of the most common malignant tumors in China. Autophagy activity and the change of Nrf2- ARE pathway play an important role in the process of liver tumors. Nrf2 which is an important regulator to liver cancer belongs to the CNC family. Research discovered that after the inhibition of autophagy, Nrf2- ARE pathway activation contributes to the progression of hepatocellular carcinoma. This article summarizes the rela- tionship between autophagy and the Nrf2-ARE pathway and its impact on the hepatic carcinoma.