阴阳因子-1在三阴性乳腺癌中的表达及其与患者预后关系的研究

Expression and predictive value of YinYang - 1 in triple - negative breast cancer patients

目的探讨阴阳因子-1（YinYang-1，YYl）在三阴性乳腺癌组织中的表达及其与临床病理特征和预后的关系。方法采用免疫组化S—P法检测87例三阴性乳腺癌组织及123例非三阴性乳腺癌组织中YY1蛋白的表达情况，并分析其与临床、病理特征的关系及其对预后的影响。结果三阴性乳腺癌组织中YY1蛋白表达率为63．2％（55／87），在非三阴性乳腺癌中的表达率为48．8％（60／123），差异具有统计学意义（P〈0．05）。在三阴性乳腺癌中YYI阳性表达与乳腺癌组织学分级（P〈0．05）、肿瘤大小（P〈0．01）及腋窝淋巳结转移相关（P〈0．01）。非三阴性乳腺癌中，YY1阳性表达仅与腋窝淋巴结转移相关（P〈0．05）。三阴性乳腺癌患者中，YY1阳性表达者的5年无病生存期（DFS）及总生存期（OS）明显低于YY2阴性表达者（分别为P〈0．01和P〈0．05）。结论YY1蛋白表达与三阴性乳腺癌浸润和转移有一定关系，YY1蛋白表达与三阴性乳腺癌患者生存期密切相关，检测YY1蛋白表达可作为判断三阴性乳腺癌预后的参考指标。

Objective To investigate expression and predictive value of YinYang - 1 （ YY1 ） in triple - negative breast cancer,and to determined whether the expression can predict survival. Methods The expressions of YY1 proteins were studied in 87 triple - negative breast cancer samples and 123 non - triple negative breast cancer samples by SP immunohistochemical staining. Furthermore, the relationships between the expressions of YY1 and clinic pathological characteristics in two groups were analyzed. The follow - up of these 210 patients was performed to evaluate the correlation between YY1 expression and prognosis. Results The positive rates of YY1 expressions in 87 triple - negative breast cancer samples and 123 non - triple negative breast cancer samples were 63.2% （55/87）and 48.8% （60/123）, respectively. In triple - negative group, YY1 expression was related with histological grade, tumor size and lymph node metastasis （ P 〈 0.05, P 〈 0.01 and P 〈 0.01, respectively）. In non-triple negative group,YY1 expression was only related with lymph node metastasis. Survival analysis suggested that the 5-year Disease-free survival rate（DFS） and Overall survival rate（OS） in patients with positive expres-sion of YY1 protein were lower than in those with negative expression（ P 〈 0.01 and P 〈 0.05, respectirely）. Conclusion The expression of YY1 was high in triple - negative breast cancer and closely related with progno-sis. Thus,it was significant in predicting the prognosis of triple - negative breast cancer.