摘要
目的评价FOLFOX6方案治疗进展及转移胃癌的疗效与毒副反应。方法37例晚期胃癌患者接受FOLFOX6方案化疗,即:奥沙利铂100mg/m^2加入5%葡萄糖250mL静滴2h,d1;亚叶酸钙400mg/m^2加入0.9%生理盐水250mL静滴2h后,立即静推5-氟尿嘧啶400mg/m^2,微泵持续静滴2400mg/m^2共46小时。每2周重复,2次为1周期。完成2个周期后判定疗效。结果入组观察37例,总有效率48.6%,初治有效率66.7%,复治有效率40.0%。中位肿瘤进展时间5.6个月,中位生存期8.3个月。毒副反应主要是恶心、呕吐、白细胞下降、末梢神经炎等,无化疗相关死亡。结论FOLFOX6方案治疗晚期胃癌疗效确切且相对安全,值得进一步研究和积极应用。
Objective To evaluate the progress and the transfer of FOLFOX6 regimen efficacy and toxic-ity in gastric cancer. Methods 37 patients with advanced gastric cancer patients were received FOLFOX6 regi-men,namely: oxaliplatin 100 mg/m^2 and 5% glucose infusion 250 mL 2 - hour drip on day 1, leucovorin 400 mg/m^2 and 0.9% saline infusion 250 mL 2 - hour drip afterwards. It was followed by 5 - fluorouracil 400 mg/m^2, bolus, and micro pumps continuous infusion 2 400 mg/m^2 for 46 hours. It was repeated every 2 weeks and 2 times for 1 cycle. Two cycles were used to determine efficacy. Results 37 patients were evaluated(48.6% total efficiency). Period and initial treatment with 66.7% efficiency were re - treated with 40.0% efficiency. The median time for progresion was 5.6 months, and median overall survival was 8.3 months. Toxicity was mainly nausea, vomiting, leukopenia and peripheral neurotoxicity. There was no chemotherapy - related death. Conclu-sion FOLFOX6 regimen in advanced gastric cancer is effectively and relatively safe. It is worth further studing and active applications.
出处
《实用肿瘤学杂志》
CAS
2012年第6期537-539,共3页
Practical Oncology Journal