瘦素及其受体与黑色素瘤的研究进展

Leptin and its receptors in melanoma research progress

恶性黑色素瘤是一种起源于黑素细胞的皮肤癌症。虽然它只占皮肤癌症的4％，但是它占到皮肤癌症死亡数的75％。流行病学和动物实验证明肥胖和黑色素瘤的发生有关系。而瘦素作为一种激素对肥胖起到促进作用。瘦素对肿瘤细胞具有刺激生长、转移、侵袭及促血管生成作用，在黑色素瘤尤其是晚期黑色素瘤中瘦素及其受体过度表达。本文将对瘦素及其受体与黑色素瘤的最新研究进展作一简要综述。

Malignant melanoma is the skin cancer that originated in the melanocytes. Although it ac-counts for only 4 percent of skin cancer,it accounted for 75% of skin cancer deaths. Epidemiology and animal ex-periments show that obesity has relationship with the occurrence of melanoma. Leptin as a hormone plays a cata-lytic role in obese. Leptin can stimulate the growth ,metastasis,invasion and pro-angiogenic in melanoma（ espe-cially leptin and leptin receptor overexpression in advanced melanoma）. This article will be of leptin and its re-ceptor and melanoma of the latest research progress for a brief overview.