心血管病患者与健康成人心率变异性的比较

Comparison of heart rate variability in patients with cardiovasc disease and healthy people

目的比较心血管疾病与健康成人的心率变异性。方法应用12通道动态心电图对273例心血管病患者(实验组)与210例健康成人(对照组)的HRV时域和频域指标进行对比分析。HRV时域指标:24h全部窦性RR间期的标准差(SDNN)、24h连续5min窦性RR间期均值标准差(SDANN)、相邻RR间期差值均方根(rMSSD)、相邻窦性RR间期差值大于50ms的百分比(PNN50);HRV频域指标:总功率(TP)、极低频功率(VLF)、低频功率(LF)、高频功率(HF)及LF/HF。结果心血管病患者的年龄、SDNN、SDANN、rMSSD、TP及VLF较对照组差异有统计学意义(p<0.05),而PNN50、LF、HF及LF/HF差异无统计学意义(p>0.05)。结论心血管病患者心脏自主神经调控功能紊乱,迷走神经活性降低,交感神经活性增强。

Objective To compare heart rate variability（HRV） in patients with cardiovasc disease and healthy people. Methods 273 cases with cardiovasc disease were selected as experimental group and 210 healthy people control group. All of them had 24h dynamic electrocardiogram record and their HRV time domain and frequency domain indicators were calculated. Result The age, SDNN, SDANN, rMSSD, TP and VLF of the patients with cardiovasc disease had statistical significance （p0.05,p0.01）, compared with those of control group. While PNN50, LF, HF and LF/HF differences had no statistical significance （p0.05）. Conclusion Function disorder of autonomic nerve developed in elder patients with cardiovasc disease. The activity of vagus nerve attenuates, while the activity of sympathetic nerve accentuates relatively. The preditive value of HRV exists in the prognosis of the patients with cardiovasc disease.