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抗心律失常新药维纳卡兰在房颤治疗中的应用

Application of the new antiarrhythmic drug vernakalant in the treatment of atrial fibrillation
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摘要 恢复和维持窦性心律是房颤(AF)治疗的重要策略。默克公司开发的维纳卡兰对急性AF转复的疗效优于其他药物,有可能成为替代胺碘酮的有效药物。本文综述维纳卡兰药动学特点、作用机制、疗效及安全性。 To convert and maintain sinus rhythm is an important strategy in the treatment of atrial fibrillation （AF）. Vernakalant developed by Merck has more effective in coverting shnus rhythm of acute AF than other drugs. It may be a substitute of amiodarone. This review describes the pharmacokinetic characteristics, mechanism, efficacy and safety of vernakalant.
作者 陈正奕 沈世峰
机构地区 黄浦区瑞金二路街道社区卫生服务中心
出处 《世界临床药物》 CAS 2012年第12期760-762,766,共4页 World Clinical Drug
关键词 抗心律失常 治疗 房颤 应用 新药 药动学特点 赛性心律 安全性 atrial fibrillation antiarrhythmic drug vemakalant sinus rhythm
分类号 R541.7 [医药卫生—心血管疾病] R972.2 [医药卫生—药品]
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参考文献13

  • 1Zhou Z,Hu D. An epidemiological study on the prevalence of atrial fibrillation in the Chinese population of China's Mainland[J].Journal of Epidemiology,2008,(05):209-216.
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  • 3Camm AJ,Capucci A,Hohnloser SH. A randomized active-controlled study comparing the efficacy and safety vernakalant to amiodarone in recent-onset atrial fibrillation[J].Journal of the American College of Cardiology,2011,(03):313-321.
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  • 5Kowey PR,Dorian P,Mitchell LB. Veroakalant hydrochloride for the rapid conversion of atrial fibrillation after cardiac surgery:a randomized,double-blind,placebo-controlled trial[J].Circ Arrhythm Electrophysiol,2009,(06):652-659.
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世界临床药物
2012年 第12期

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