还原型谷胱甘肽联合水飞蓟素治疗酒精性肝病的疗效观察

The silymarin cobined with glutathione treatment of chronic alcoholic liver disease

目的观察还原型谷胱甘肽联合水飞蓟素治疗慢性酒精性肝病的临床疗效。方法将128例慢性酒精性肝病患者随机分为两组,对照组64例,观察组64例。对照组给予还原型谷胱甘肽1.2g静脉滴注1次/d;观察组在对照组基础上加用水飞蓟素140mg,2次/d口服。分别于治疗前及治疗后1个月检测两组患者肝功能指标ALT、AST、GGT、TBIL及肝纤维化指标HA、PCⅢ、IV-C等,评价其疗效。结果治疗1个月后,观察组显效52例(81.25%),有效8例(12.5%),无效4例(6.25%);对照组显效25例(39.06%),有效15例(23.43%),无效24例(37.50%);两组比较总有效率、肝功能比较,差异有统计学意义(P<0.05)。结论水飞蓟素联合还原型谷胱甘肽治疗慢性酒精性肝病疗效显著,两药联合优势互补。

Objective The therapeutic effect of the silymarin combined with glutathione on chronic alcoholic liver disease was studied. Methods 128 patients with chronic alcoholic liver disease were randomly divided into two groups. Control group 64 cases were treated with reduced glutathione 600 mg once a day.The observation group added Silymarin 140 mg bid po. On the basis of the control group. Respectively,liver function and liver fibrosis index were tested between the two groups before treatment and after 1 month treatment in patients. Results After one month of treatment, the observation group,52 cases （81.25%） were markedly effective,8 patients （12.5%） were effective, 4 cases （6.25%） were ineffective;the control group, 25 cases （39.06%） were markedly effective, 15 cases （23.43%） were effective, 24 cases （37.50%） were ineffective; total efficiency in the group （P0.05）, comparison of liver function（P0.05）,the difference was statistically significant.Conclusion Silymarin combined with glutathione can significantly improved clinical treatment effect of chronic alcoholic liver disease,synergistic effect were existed between the two drugs.