舒芬太尼、芬太尼用于开胸术后镇痛的对比观察

Clinic effect of sufentanil and fentanyl for postoperative patient-controlled induce analgesia after thoracic operation

目的分析探讨舒芬太尼和芬太尼用于患者自控静脉镇痛(PCIA)的镇痛效果和不良反应。方法选择ASAⅡ～Ⅲ级择期开胸手术患者74例,随机分成舒芬太尼(观察组)和芬太尼(对照组),每组各37例。分别记录术后4h、8h、l2h、24h、48h各时间段内的疼痛、镇静、恶心、呕吐评分。结果术后4h、8h、l2h、24h、48h各时间段内观察组的疼痛、镇静评分均低于对照组(P<0.05);两组患者不良反应发生率比较差异无统计学意义(P>0.05)。结论舒芬太尼用于开胸手术后静脉镇痛效果确切,不良反应少,镇静效果好,优于芬太尼,值得临床上推广使用。

Objective To compare the clinic effect and safety of sufentanil and fentanyl for postoperative patient-controlled induce analgesia after thoracic operation.Methods 74 ASAⅡ~Ⅲ patients undergoing thoracic operation were randomly divided into sufentanil group （observation group） and fentanyl group （control group）each in 37 cases. The pain intensity, cumulative analgesic consumption, sedative scores and side effects at 4 h, 8 h, l2 h,24 and 48 h after administration were recorded.Results There were significant differences in pain intensity and sedative scores between the two groups （P0.05）,and the untoward reaction rate were no significant differences between the two groups （P0.05）.Conclusion Sufentanil could be used in patient-controlled intravenous analgesia after major thoracic surgery with satisfactory effect and less side effect which indicates the good prospect of sufentanil in clinical postoperative analgesia.