长托宁救治有机磷农药中毒疗效体会

目的分析体会长托宁治疗有机磷农药中毒临床疗效。方法对我院2006年6月至2010年6月应用长托宁救治46例有机磷农药中毒患者进行观察。结果治疗组有1例死亡,救治成活率97.8%。对照组有7例死亡,救治成活率85%;经校正卡方检验,差异有非常显著性χ2=7.86,P<0.01,治疗过程中,未发现有不良反应。结论长托宁救治有机农药中毒能迅速增强机体的抗胆碱作用,疗效好,副作用小,病程短,费用低,治愈率高,死亡率低,临床应用效果极好。

Objective To analyze the penehyclidine hydrochloride （PHC） in treatment of organophosphorus pesticide poisoning in the clinical efficacy. Methods To observe the therapeutic effect of PHC to cure the 100 patients who were poisoned by organic phosphorus pesticide from June, 2006 to 2010 in our hospital. Results The treatment group had one death, and the survival rate was 97.8%. However, there were seven deaths in the control group, and only 85% survival rate. No adverse reactions in the treatment group. Furthermore, upon testing via calibration chi-square we can see that treatment group was superior to control group and the difference was significant （χ2=7.86,P0.01）. Conclusion PHC can rapidly improve the body anti-cholinergic effects in the treatment of patients with organophosphorus pesticide poisoning. What is more, the PHC has the significant advantage of being effective, less adverse reaction, short disease course, low costs high curative rate, low death rate and has extremely good clinical results.