系列D-2-氨氧基酸的合成

Synthesis of D-α-aminoxy acids

通过天然氨基酸的重氮化、保护、以及与邻苯二甲酰亚胺的Mitsunobu反应、脱保护等步骤高效的合成一系列高立体选择性的氨氧基酸类化合物.其中,Mitsunobu反应是关键步骤,它构建分子中的N—O键,并翻转分子的手性中心.

A series of chemical compounds of aminoxy acids with high stereoselectivity were effectively synthesized with such procedure as diazotization, protection, Mitsunobu reaction with phthalimide and de- protection. Mistunobu reaction was the key step, which formed the N--O bonds in the molecule and re- versed the chiral centers of the molecule.