代谢综合征与大肠腺瘤的相关性研究

Study of the relationship between metabolic syndrome and colorectal adenoma

目的研究代谢综合征（MS）与大肠腺瘤的相关性。方法选取2009年6月～2012年6月所有接受结肠镜检查的患者，根据排除标准及肠镜检查结果诊断大肠腺瘤组455例，同时选取同期年龄匹配，肠镜结果未见异常的体检者455例为对照组。所有研究对象均检查空腹血糖、血脂，并测量血压、腰围，记录肠镜下腺瘤分布部位、大小、病理结果。对大肠腺瘤组与对照组各临床参数进行比较，运用Logistic回归分析代谢综合征与大肠腺瘤的相关性。结果（1）大肠腺瘤组代谢综合征患病率高于对照组（P〈0．01），代谢综合征及血糖异常是大肠腺瘤的独立危险因素；（2）代谢综合征病种数量在个体聚集越多，患大肠腺瘤可能性越大；（3）大肠腺瘤合并代谢综合征患者大肠腺瘤数目多为3个或以上，大小为5～9mm，病理多呈进展性改变。结论代谢综合征与大肠腺瘤密切相关，尽早对代谢综合征患者行结肠镜检查，有利于大肠腺瘤的防治。

Objective To explore the relationship between metabolic syndrome （MS） and color- ectal adenoma（CRA）. Methods All cases who received colonoscopy from Jun,2009 to Jun,2012 in our hospital were divided into CRA group（ n = 455） and matched controls（ n = 455）. The diagnosis of CRA is based on the exclusion criteria and colonoscopy examination. Blood glucose, blood lipids, blood pressure, waist circumference,weight, height and blood uric acid were measured. The characteristics of CRA were recorded, and the clinical features between CRA and control group were compared. Logistic regression was used to analyze the association between MS and CRA. Results The morbility rate of MS in CRA group was significantly higher than that in the control group（ P 〈0.01 ）. MS and abnormal blood glucose were in- dependent risk factors for CRA. The incidence of CRA increased with the clustering components of MS. In CRA patients with MS,those CRA with number of multiple（≥3 ） or with size of 5-9 mm（diameter） usu- ally have progressive biopsy change. Conclusion MS is associated with CRA. The patient with MS should accept colonoscopy earlier,which is benefit for the prevention and treatment of CRA.