负荷与静息门控核素心肌灌注显像左心室不同步参数的差异性研究

Difference study of left ventricular dyssynchrony parameters with stress and rest gated myocardial perfusion SPECT imaging

目的比较负荷与静息门控核素心肌灌注SPECT显像（G-MPS）相位分析技术（SyncT001）所测定的左心室不同步参数之间是否存在差异。方法回顾性入选行负荷／静息G—MPS的正常对照组患者60例、心肌缺血组患者40例和心功能不全组患者40例，各有一半接受运动或腺苷负荷G-MPS。应用SyncTool对负荷／静息G—MPS短轴图像进行相位分析，计算出左室不同步参数相位标准差（PSD）和相位直方图带宽（PHB）。结果各组患者运动负荷与静息G-MPS的左心室不同步参数（PSD、PHB）均无明显差异（P〉0．05），腺苷负荷与静息G-MPS的上述参数也均无明显差异（P〉0．05）。将心功能不全组分为缺血性心肌病与扩张型心肌病两个亚组，各亚组负荷与静息G—MPS的左心室不同步参数（PSD、PHB）均无明显差异（P〉0．05）。结论负荷试验（运动或腺苷）后1小时采集的99Tc-sestamibiG-MPS所获得的PSD和PHB与静息G-MPS所获得的上述参数无显著差异，常规负荷G—MPS可以用于左心室同步性分析。

] Objective To determine whether LV dyssynchrony parameters measured by Phase a- nalysis with stress gated myocardial perfusion SPECT imaging （G-MPS） significantly differed from those with rest G-MPS. Methods 60 normal subjects,40 patients with ischemia,and 40 patients with LV dys- function were enrolled and retrospectively studied. Half of them underwent exercise stress/rest G-MPS, an- other half underwent adenosine stress/rest G-MPS. The short axis data from rest and stress were then sub- mitted to SyncTool for measuring phase standard deviation （PSD） and phase histogram （PHB）. Results There were no significant difference of LV dyssynchrony parameters （ PSD or PHB） between stress （ exer- cise or adenosine） and rest G-MPS in each group（ P 〉 0.05 ）. When doing analysis in patients with LV dysfunction in each subgroup （ischemic cardiomyopathy and dialated cardiomyopathy） ,the rest and stress PSD or PHB were similar respectively （ P 〉 0.05 ）. Conclusion LV dyssynchrony parameters measured by phase analysis of stress G-MPS have the same clinical value with that of rest G-MPS.