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急性心肌梗死患者行主动脉内球囊反搏治疗前后抑郁评估及其预后意义 被引量:1

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摘要 目的探讨急性心肌梗死患者接受主动脉内球囊反搏(IABP)治疗后抑郁的发生情况及其对患者预后的影响。方法应用抑郁自评量表(SDS),对292例急性心肌梗死且接受IABP治疗的患者在治疗前后不同时间段进行抑郁评分,根据结果分为抑郁组和非抑郁组,分析两组患者1年主要不良心m管事件(MACE)的发生率。结果急性心肌梗死患者接受IABP治疗前抑郁发生率为28.1%,IABP术后24小时内抑郁发生率为53.4%,术后3天抑郁发生率为61.5%,3个时间段抑郁发生率比较差异有统计学意义(P〈0.05);患者3个时间段的SDS分值比较差异有统计学意义(P〈0.05)。以IABP治疗前抑郁情况分组,与非抑郁组相比,抑郁组患者1年内MACE事件的发生率显著增高(45.1%比29.O%,P〈0.05),靶血管重建率也显著增加(22.3%比18.1%,P〈0.05);以IABP术后24小时患者抑郁情况分组,抑郁组患者的一年内MACE事件发生率较非抑郁组显著增高(45.7%比30.2%,P〈0.05),靶血管重建率也有显著增加(19.2%比10.1%,P〈0.05);以IABP术后3天时患者抑郁情况分组,抑郁组患者1年内MACE事件的发生率较非抑郁组显著增加(63.7%比29.8%,P〈0.05),靶血管重建率也显著增加(23.0%比10.5%,P〈0.05),1年内死亡率显著增加(30.8%比17.5%,P〈0.05),再次心肌梗死发生率也显著上升(9.8%比1.8%,P〈0.05)。结论急性心肌梗死患者在接受IABP治疗后有较高比例的抑郁发生,合并抑郁的心肌梗死患者有较高的MACE事件发生率,且长时间留置IABP导管可能增加患者抑郁程度,并因此增加心血管事件风险。
出处 《临床内科杂志》 CAS 2012年第12期836-838,共3页 Journal of Clinical Internal Medicine
基金 基金项目:南京医科大学科技发展项目(09NJMUM0715) 南京市医学科技发展项目(QYK09159)
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