羧甲淀粉钠溶液对反复呼吸道感染儿童外周血T淋巴细胞亚群的影响及疗效

Influence of Carboxyl Methyl Starch Sodium Solution on Peripheral T-lymphocyte Subsets in Children with Recurrent Respiratory Tract Infections

目的:观察羧甲淀粉钠溶液对反复呼吸道感染(RRI)儿童外周血T淋巴细胞亚群的影响及疗效。方法:RRI患儿68例,随机分为观察组(35例)与对照组(33例)。两组患儿均予抗感染、抗病毒、退热和止咳化痰等综合性治疗。观察组患儿在此基础上口服羧甲淀粉钠溶液,连用6个月。比较两组患儿治疗前后外周血T淋巴细胞亚群的变化,并进行临床疗效和不良反应的观察。结果:治疗6个月后,观察组患儿外周血CD_4^+水平和CD_4^+/CD_8^+比值均较治疗前明显上升,CD_8^+水平较治疗前明显下降(P<0.05或0.01),而对照组治疗前后CD_4^+、CD_8^+水平和CD_4^+/CD_8^+比值无明显变化(P>0.05)。观察组疗效(91.43%)明显优于对照组(66.67%),差异有统计学意义(P<0.05)。两组治疗期间均无明显不良反应发生。结论:羧甲淀粉钠可纠正儿童RRI外周血T淋巴细胞亚群功能紊乱,改善患儿的细胞免疫失衡状态,治疗儿童RRI疗效确切,安全性好。

Objective：To explore the influence of carboxy methvl starch sodium solution on peripheral T-lymphocyte subsets in children with recurrent respiratory tract infections（RRI）.Method：Totally 68 children with RRI were divided into the observation group（35 cases） and control group（33 cases） randomly.All the patients received comprehensive treatment such as anti-infective, antivirus,antipyretic,cough-relieving and expectorant,and the observation group was administrated carboxy methyl starch sodium solution for 6 months additionally.The levels of peripheral T-lymphocyte subsets before and after the treatment were observed,and so were the clinic efficacy and side effect.Result;At the 6th month after the treatment,the levels of CD_4~＋ and the rate of CD_4~＋ /CD_8~＋ increased significantly compared with those before the treatment,while CD_8~＋ was decreased（P0.01 or P0.05 ）.And there were no differences in the levels of CD_4~＋ and CD_8~＋ and the rate of CD_4~＋ /CD_8~＋（P0.05 ）.The clinic effect of observation group showed much better than that of the control group（P0.05）.There was no obvious side effect appeared in both groups during the treatment. Conclusion：Carboxy methyl starch sodium solution maybe an ideal drag to treat children with RRI for the certain clinic curative effect and high-safety.It can improve the dysfunction of peripheral T-lymphocyte subsets and the imbalance of cellular immunity.