2010年四川省麻疹抗体水平监测

Surveillance of Measles Antibody Level in Sichuan Province,2010

目的了解四川省人群中麻疹抗体水平,评价免疫策略的效果,为针对麻疹的免疫决策提供科学依据。方法于2010年按照麻疹发病率分层随机抽取6个抽样点(8个县区),共调查1 269人,检测血清麻疹IgG水平。结果被检测人群中,麻疹抗体阳性率为93.07%,抗体几何平均浓度(GMC)为1 775.30(95%CI:1701.10～1 849.80)。1岁以上各年龄组抗体阳性率和抗体浓度均较高;婴儿在3月龄后抗体阳性率下降明显;8～11月龄儿童接种首剂次麻疹疫苗的抗体阳性率为86.57%;育龄妇女的抗体水平维持在较高水平;巴州区的14岁以下人群标准化抗体阳性率低于90%,发生了麻疹暴发疫情。结论四川省1岁以上人群麻疹抗体水平较高,但婴儿抗体水平衰减较快,加强育龄期妇女接种对控制婴儿发病的作用比较有限;有必要及时接种2剂次麻疹疫苗接种。

Objective To investigate the measles antibody level in Sichuan province and evaluate the effect of immunization strategy,so as to provide scientific evidence for decision-making.Methods A total of 1269 cases from 8 counties were randomly selected with stratified sample method according to measles incidence distribution,and level of measles IgG of whose was tested.Results Of all measles cases the positive rate was 93.07% and the average antibody concentration was 1775.30 mIU/ml（95%CI：1701.10-1849.80）.The geometric mean concentration（GMC） and seropositive rate of children above 1 year old were both relatively high;the seropositive rate of infant dropped significantly after 3 months;the positive conversion rate of the first dose measles vaccine targeted 8-11 months children was 86.57%;the seropositive rate of childbearing age women maintained at a relatively high level;the standardized seropositive rate of the population under 14 years old at Bazhou county was less than 90%,resulted in a measles outbreak.Conclusion The antibody level of children above 1 year old is relatively high;yet the antibody level of infants drops fast;immunization inoculation targeted childbearing age women has limited effects on the incidence of infant and the second doses measles vaccine are necessary.