内皮素-1在乳腺癌组织中的表达及临床意义

Expression of Endothelin-1 in breast carcinoma

目的研究内皮素-1(ET-1)在乳腺癌组织中的表达及临床意义。方法采用免疫组织化学法检测乳腺癌组织、乳腺纤维腺瘤及癌旁正常组织中ET-1的表达,结合乳腺癌临床分期进行统计学分析。结果 ET-l在乳腺癌组织、乳腺纤维腺瘤及癌旁正常组织中的阳性表达相比,差异有统计学意义(P<0.05);ET-l在乳腺癌组织中阳性表达最高,在癌旁正常组织中阳性表达最低。ET-1在乳腺癌各临床分期标本中的表达均差异有统计学意义(P<0.05),分期越晚,表达越高。结论 ET-1在乳腺癌中呈高表达,在乳腺癌的发生、发展中可能具有重要作用。

Objective To study the expression and clinical significance of Endothelin-1 in breast carcinoma. Methods Immunohistochemical method was used to detect the expression of Endothelin-1 in breast carcinoma,breast benign lesions and adjacent normal breast tissue.The relationship between the expression of Endothelin-1 and the clinic stage was analyzed by SPSS1 6.0 software. Results The positive expression of Endothelin-1 in all three type tissues.There is a significant difference between the breast carcinoma and the breast benign lesions,the breast carcinoma and the adjacent normal breast tissue,the breast benign lesions and the adjacent normal breast tissue（P0.05）.The highest expression of Endothelin-l was in breast carcinoma tissue.In breast carcinoma tissue,the advanced clinical stage,the more higher expression of endothelin-1. Conclusions Positive expression of Endothelin-1 in breast carcinoma tissue is highest in three tissue.It may play an important role in carcinogenesis and progress of breast carcinoma.