妊娠梅毒患者血清IL-4和IFN-γ水平的检测及意义

Determination of Serum IL-4 and IFN-γin Syphilitic Patients with Pregnancy and Its Clinical Significance

目的探讨白细胞介素4(IL-4)、干扰素-γ(IFN-γ)在妊娠梅毒发病机制中的意义。方法采用双抗体夹心ELISA法检测9例活动期妊娠梅毒患者血清中IL-4和IFN-γ的水平,并以20例正常孕妇作为对照。结果 9例活动期妊娠梅毒患者与正常对照组比较,血清IL-4、IFN-γ水平明显增高(P<0.01)。结论 IL-4和IFN-γ参与了梅毒螺旋体进入体内后的免疫过程,可能在梅毒螺旋体的清除过程中发挥重要的免疫调节作用。

Objective To investigate the role of interleukin-4（IL-4） and interferon-gamma（IFN-γ） In the pathogenesis of syphilis with pregnancy. Methods The levels of Serum IL-4 and IFN-γ in 9 patients in active phase of the disease,18 patients in recovery phase of the disease,and 20 healthy pregnancy were measured by ELISA method. Results The levels of Serum IL-4 and IFN-γin 9 patients in active phase of the disease were remarkably higher as compared with those in the control group（P0.01）. Conclusions This study showed that IL-4 and IFN-γmay be involved in the control of infection.It may also play a role in the clearance of the TP（Treponema pallidum） from the boby.