艾滋病患者抗病毒治疗后CD4^+T淋巴细胞计数变化及影响因素调查

Changing of CD4+T cells numbers in AIDS patients after antiviral treatment and its affecting factors

目的了解艾滋病患者抗病毒治疗后CD4+T淋巴细胞计数变化情况及影响其变化的因素。方法青岛市自2005年免费抗病毒治疗开始截止到2012年2月底,所有参与免费抗病毒治疗满1年且依从性良好的109例成人患者,从青岛市艾滋病患者随访管理档案和"艾滋病综合防治数据信息管理系统"中获取资料,将资料按照治疗前CD4+T淋巴细胞水平、年龄、性别、婚姻和传播途径分组。结果 109例成人患者治疗3个月后,87.16%的患者CD4+T淋巴细胞出现不同程度的上升;治疗6个月后和12个月后,治疗前CD4+T淋巴细胞≤200组和>200组之间细胞计数的增长差异有统计学意义(P<0.05);年龄≤40岁组和>40岁组在治疗6个月后CD4+T淋巴细胞计数的增长差异有统计学意义(P<0.05)。结论早期治疗可以及时控制病毒复制,防止免疫损伤的进展,有利于维持和重建免疫功能,从而延迟疾病的进展,过晚的治疗不利于患者免疫功能的恢复。

Objective To study the changing of CD4 ＋ T cells numbers in AIDS patients after antiviral treatment and its af- fecting factors. Methods From 2005 when free antiviral treatment started in Qingdao to the end of February 2012, a total of 109 patients with AIDS were selected who presented a good compliance to take antiviral therapy over one year. Their in- formation were obtained from the follow - up files of the AIDS in Qingdao and database management system of AIDS preven- tion and control, including CIM ＋ T cells numbers before treatment, age, sex, marriage and transmission routes, which were the basis for group division. Results After a three - month treatment, the increase of CD4 ＋ T cells numbers oc- curred in 87.16% of the patients to varying degrees. Further more, basing on whether the number of the patientg CD4 ＋ T cells exeeeded 200, the patients were divided into two groups before treatment. Comparing the number of CD4 ＋ T cells of both groups respectively after a six - month and twelve - month treatment, the growth of this number was statistically signifi- cant （ P 〈 0.05 ）. Signifieant difference was also found in the increase of CD4 ＋ T cells between the group at 40 years of age or less and the group over 40 years of age （ P 〈 0.05 ）. Condusions Early intervention can eontrol the replication of viru- ses in time and prevent the progression of immunological injury, which is condueive to the maintenance and reconstruction of immune function and can delay disease progression. The treatment which is taken too late is unfavorable for the recovery of immune function.