上消化道多原发性癌临床分析

Multiple primary cancers of upper gastrointestinal tract

目的 探讨本地区上消化道多原发性癌的某些临床特点。方法 回顾性分析我院 2 4年内 119例上消化道多原发性癌的临床资料。结果 发病高峰年龄为 5 1～ 70岁 ,男性多于女性 ,体力劳动者较脑力劳动者高。同时性和异时性上消化道多原发性癌两癌灶发生的平均间隔时间分别为 0 12个月和 4 7年 ;同时性和异时性食管多原发性癌、胃多原发性癌和食管、胃多原发性癌的好发部位分别为食管中段 -下段、胃窦 -贲门和食管中段 -胃体 ;癌灶手术后病理检查以食管鳞状细胞癌和胃粘液腺癌多见。结论 内镜检查时仔细观察上消化道全程 。

Objective The clinical features of multiple primary cancers in upper gastrointestinal (UGI) tract were studied Methods 119 cases with such cancers were encountered in our hospital through past 24 years ; the documents collected and reviewed Results Regarding incidence, 51-70 years of age appeared to be the peak ; males > females; physical laborers > sedentary workers The average interval when multiple cancers were discovered “synchronously”or “metachronously”varied from 0 12 month to 4 7 years respectively ,the most frequent sites involved were mid-lower esophagus, cardia ,and antrum of stomach Pathology of resected specimens often showed malignant squamous cells (esophagus) and mucoid adenocarcinomas (stomach) Conclusion During gastroscopy meticulous observation throughout the UGI tract and taking biopsies from sites between suspected lesions are mandatory to reveal multiple primary cancers