快速老化小鼠SAMP8在阿尔茨海默病研究中的应用

Senescence Accelerated Mouse Prone 8 for Study of Alzheimer's Disease (review)

阿尔茨海默病以进行性认知功能障碍、记忆能力下降为主要特征。脑内β-淀粉样蛋白(Aβ)异常沉积、神经原纤维缠结、胆碱能神经元功能减退、突触和树突棘缺失等为阿尔茨海默病特征性病理改变。快速老化小鼠SAMP8在早期即出现学习记忆功能障碍、Aβ异常沉积、tau蛋白磷酸化、神经递质改变、突触结构和功能障碍、生理节律紊乱,以及基因表达等多方面的特征性改变,与人类阿尔茨海默病病理改变较为一致,可以作为较理想的动物模型,用于阿尔茨海默病防治药物的研究。

Alzheimer＇s disease （AD） is a neurodegenerative disorder characterized by memory loss and cognitive decline. The patholog- ical features of Alzheimer＇s disease are abnormal deposition of amyloid beta-peptides （A[3）, neurofibrillary tangles, cholinergic deficits, and loss of synaptic processes and dendritic spines. Senescence accelerated mouse prone 8 exhibits age-related deficits of learning and memory from an early age, tau protein phosphorylation, neurotransmitter changes, synaptic structure and function disorders, circadian rhythm disor- ders, as well as gene expression and many other characteristic changes, which are consistent with Alzheimer＇s disease pathological chang- es, and can be used as an ideal animal model for Alzheimer＇s disease prevention drugs development.