阿司匹林抵抗与基因多态性

Aspirin resistance and single nucleotide gene polymorphism

阿司匹林作为一种有效的抗血小板聚集药,在心脑血管病防治中方面发挥着重要作用。然而,阿司匹林抗血小板作用个体差异较大,部分患者存在阿司匹林抵抗(Aspirin resistance,AR),其发生机制尚未明确。新近研究表明,AR与环氧合酶、纤维蛋白原受体、ADP受体和胶原受体等的基因多态性密切相关。因此,基因多态性的检测不仅有助于阐明AR的发生机制,同时也将为实现个体化治疗策略以及临床转归的评估提供理论基础。

Aspirin is an effective anti-platelet aggregation of medicine which is playing a vital role in the prevention and treatment of cardio cerebral vascular disease.However,there exists individual difference in its anti-platelet effect,Aspirin resistance is presented in some of patients and the occurrence mechanism is still unknown.New clinical trials suggest that Aspirin resistance is closely related to the genetic polymorphism of cycloxygenase,fibrinogen receptor,adenosine diphosphate receptor,glycoprotein,and so on.Therefore,detection of gene polymorphism not only contributes to the elucidation of the mechanism,but also provides the theory basis to the strategy individualized treatment and clinical outcome.