派莎防晒霜的体外释放度考察

Determination of release rate of the sun screen parsol in vitro

目的考察派莎防晒霜的体外释放度,为处方设计、制备工艺、质量评价及合理应用提供依据。方法采用透析袋-高效液相色谱法研究其体外释药特性,以生理盐水为释放介质,甲醇-四氢呋喃-水-高氯酸(60∶100∶80∶0.05)为流动相,检测波长:357 nm;流速:1 mL/min,进样量10μL,柱温25℃。结果 12 h内,parsol1789(丁基甲氧基二苯甲酰甲烷)累积释放度为8.2%。结论派莎防晒霜具有缓释特性和良好的防晒效能。该方法用于考察派莎防晒霜的体外释放度,操作便利、方法稳定、结果重现性好。

Objective To provide the foundation for prescription design,preparation technology,quality evaluation and rational use of the sun screen Parsol by studying its in-vitro release rate.Methods Saline solution was the release medium,and the release rate of the sun screen Parsol was researched with the dialysis method and HPLC.The methanol-tetrahydrofuran-water-perchloric acid（60∶ 100∶ 80∶ 0.05）was the mobile phase with the wavelength of 357 nm,the flow rate was 1.0 mL/min,and the injection volume was 10 μL,the oven temperature was 25 ℃.Results The release rate of parsol 1789 was 8.2% in 12 h.Conclusion The sun screen Parsol has slow release characteristics with better sunscreen effect.The method is convenient and stable.