不同年龄段人群脂肪肝与颈动脉粥样硬化的相关性研究

Relationship between fatty liver and carotid atherosclerosis in different age populations

目的探讨脂肪肝和正常人群的颈动脉粥样硬化的患病率,分析脂肪肝与颈动脉粥样硬化的关系。方法本院体检者6 671例,年龄22～86岁,将观察人群按每10岁为一个年龄段分成6个年龄组,≤30岁,>30～40岁,>40～50岁,>50～60岁,>60～70岁,>70岁。根据肝脏超声结果将人群分为脂肪肝与正常肝两部分人群,分别统计不同年龄段、不同性别脂肪肝与颈动脉粥样硬化的患病率。结果所有体检人群中脂肪肝的检出率为36.7%(2 483/6 671),男、女人群脂肪肝检出率分别为46.3%(1 680/6 671)、25.6%(803/3 140),性别之间差异具有统计学意义(P<0.01)。脂肪肝、正常肝人群的颈动脉粥样硬化检出率分别为35.5%(881/2 483)、23.5%(984/4 188),>30岁以后各组人群脂肪肝人群的颈动脉粥样硬化患病率均显著高于正常肝组(P<0.01)。结论脂肪肝的发生早于动脉粥样硬化的发生,30岁之前仅检测到脂肪肝、30岁以后颈动脉粥样硬化开始发病,脂肪肝人群的颈动脉粥样硬化患病率明显高于正常肝人群,对脂肪肝的早期防治,可以间接的降低动脉粥样硬化的发生率。

Objective The study was to explore about the prevalence of carotid atherosclerosis in fatty liver population and normal liver people and analyze the relationship between fatty liver and carotid atherosclerosis. Methods A total of 6 671 subjects were chosen from routine body check in the hospital, age range 22-86 years old. The examination population was divided into six age groups in a section 10-year-old age,≤30 years old,〉30-40 years old, 〉40-50 years old, 〉50-60 years old, 〉60-70 years old, 〉70 years old. The population was divided into two parts：fatty liver and normal liver according to liver ultrasound, then, the prevalence of carotid atherosclerosis was respectively analyzed in different genders and ages. Results The prevalence of fatty liver in the whole population was 36.7%, males 46.3% and females 25.6 %, genders showed significant difference（ P d0.01）. The prevalence 9f carotid atherosclerosis was 35.5% and 23.5% for fatty liver group and normal liver group of the population. In the groups older than 30 years old, the prevalences of carotid atherosclerosis were significantly higher in fatty liver population than that in normal liver population in responding age group. Conclusion The occurrence of fatty liver, which was detected before the age of 30, was earlier than that of carotid atherosclerosis which was detected after 30-year-old. The prevalence of carotid atheroselerosis was obviously higher in fatty liver population than that in normal liver population. Earlier prevention and cure for fatty liver will lower the incidence of atherosclerosis indirectly.