邻硝基苯氧乙酸的合成工艺改进

Improvement on Synthesis of 2-(2-nitrophenoxy)Acetic Acid

以邻硝基苯酚和氯乙酸甲酯为原料,在碳酸钾催化下反应生成邻硝基苯氧乙酸甲酯,经碱水解、盐酸酸化得目标产物。通过实验考察了缩合反应温度,碱用量对产率的影响,得出最佳反应条件:温度为72℃,碱用量为邻硝基苯氧乙酸甲酯的1.5倍,在此条件下总产率达到78.9%。新方法原料易得、耗时短、收率高、后处理简单,工业化生产前景广阔。

2-（2-nitrophenoxy） acetic acid was obtained by three steps,using 2-nitrophenol and methyl 2-chloroacetate as starting materials and potassium carbonate as catalyst.The effect of reaction temperature and amount of sodium hydroxide on the yield were studied.When the reaction temperature was 72 ℃ and the amount of sodium hydroxide was 1.5 times as that of methyl 2-（2-nitrophenoxy） acetate and the yield reached 78.9%.New method had the advantages of convenient operation,mild reaction conditions and cheap reagents and was suitable for industrial process.