^(99m)Tc-DTPA测得空勤人员肾小球滤过率与血浆内皮素含量的关系

Relation of GFR and Endothelin in the Plasma in Pilots and Ground Crew.

观察飞行员肾小球滤过率 (GFR)特点及其与血浆内皮素 (ET)含量的关系。方法采用单光子发射计算机断层摄影术 (SPECT) ,用99m锝 -二乙撑三胺五乙酸 ( 99mTC DTPA)示踪剂 ,与放射免疫分析法 (RIA)结合 ,对 46名飞行员 ,30名地勤人员和 30名肾病病人 (均为男性 )进行GFR和ET含量测定 ,并分析它们之间的关系。结果飞行员ET与GFR无相关 ,飞行员与地勤人员肾功能无差别。肾病病人ET明显高于飞行员和地勤人员 ,GFR明显低于飞行员和地勤人员。年龄与肾总GFR存在负相关(r =- 0 .85,P <0 .0 1 )。 31岁以上年龄组飞行员ET含量较地勤组有显著性差别。结论本试验结果提示 ,飞行员、地勤人员的GFR的正常参考值可用同一标准。飞行员体内一定范围ET的升高对肾功能无影响。

Objective To observe the specitic property of Glomeoular Filtration Rate(GFR) and its relation to endothelin of plasma in pilots. Method GFR was assessed with single photon emisson computed tomography(SPECT),tracer for 99m Tc DTPA,enthlion of plasma were measured by radio immunossay in forty six poilts, thirty ground crew and renal disease patients. Result Endothelin were not correlation with GFR in pilots.GFR of pilots and ground crew had not a significant difference.Compared with ground crew and pilots, endothelin of renal disease patients had a significant increased, and GFR had a significant decreased. Age were a linear negative correlation with total GFR r=(0.84,P<0.01),flying time, age had not correlation with endothelin. After thirty one ground endothelin had a significant difference with ground crew. Conclusion It suggested that the endothelin has no influence on GFR in pilots when it was increased with in the limits of a level, pilots and ground crew may use the same stand on GFR.