肝癌转移复发监测:磁共振扩散加权成像与外周血分子生物学技术研究进展

The metastasis relapse monitors hepatocellular carcinoma:diffusion weighted MR imaging and molecular biology technology research progress

肝癌(hepatocellular carcinoma,HCC)的治疗方法日趋多样化,对治疗后的随访及监测提出了更高的要求。包括MRS、DWI及PWI在内的功能MRI是一种无创性检测方法,可以从局部及整体了解肝脏的代谢、能量及血流等的变化,其在肝脏显像中的不断发展对评价HCC治疗后的疗效及预后有着深远的意义。HCC转移复发是一个多步骤、多因素相互作用的复杂过程。在HCC转移复发的蛋白质组学研究方面,发现了很多新的潜在分子生物学标记物。由于仅用单个指标无法进行准确预测,采用多个指标进行联合检测将是今后HCC转移预测的研究方向。该文旨在揭示肝脏DWI的原理以及目前在辨别肿瘤生物学特性中的作用,评价HCC对治疗的反应,并探索性地提出了DWI在HCC转移复发监测中的应用前景,综述了所涉及HCC转移复发早诊的外周血新型分子标记物。-

Multi-treaments of hepatocellular carcinoma（HCC） place greater demands on follow-up for tumor response.Functional MRI（fMRI） which mainly contains MRS,DWI,and PWI,is a non-invasive technique which can detect regional and global alterations in liver metabolic processes and celluar energy states as well as blood flow.Continued progress in this field of liver imaging may have profound implications for diagnosing and estimating therapeutic effect of HCC.The metastasis of HCC has long been recognized as a multi-stepprocess that involves multiple factors.Insteadof diagnostic models based on single-moleculedetection,the combination of multiple molecules will be the trend for early tumor diagnosis or prediction of tumor metastasis and recurrence.Many differentially expressed metastasis-associatedgenes and proteins have been reported in HCC.The purpose of this review is to expond the principles of tin vivo hepatic f MRI,to examine its present place in the diagnostic assessment of tumor biological characteristics,to appraise the respone of the tumor to treament and to evalute the prospects for f MRI in application of prognostic tests of HCC.This article Involved in the transfer of liver cancer recurrence of novel molecular markers had peripheral blood.