热性惊厥患儿血清白细胞介素-6含量检测的临床意义

Clinical Significance of Serum IL-6 in Children with Febrile Seizures

目的探讨白细胞介素-6(IL-6)在小儿热性惊厥(FS)过程中所起的作用和临床意义。方法 50例小儿FS患者为病例组,30例门诊健康发热儿童为发热对照组,另外30例门诊正常体检儿童为健康对照组,采用ELISA法测定受检者血清IL-6含量。结果病例患儿血清IL-6含量明显高于健康发热组和健康对照组。而健康发热组和健康对照组的IL-6含量无显著性差异。结论 IL-6可能参与了小儿热性惊厥(FS)的发生发展。

Objective To investigate the role and clinical significance of interleukin-6（IL-6） in febrile seizures（FS）.Methods The serum levels of IL-6 were measured by ELISA in 50 children with FS,30 children with normal fever and 30 healthy children.Results The serum level of IL-6 in children with FS was significantly higher as compared to other two groups.No significant difference was found between the serum level of IL-6 in normal fever children and that in healthy children.Conclusion IL-6 may play an important role in the pathogenesis of FS.