甲氨蝶呤不同方案治疗输卵管妊娠的效果探讨

Discussion on the Effect of Different Methotrexate in the Treatment of Tubal Pregnancy

目的探讨甲氨蝶呤不同方案治疗输卵管妊娠的临床效果。方法将患者分为Ⅰ组、Ⅱ组和Ⅲ组,分别采用甲氨蝶呤联合米非司酮和甲氨蝶呤不同剂量(50mg/m2和100mg/m2)进行治疗,比较三组治疗后的整体效果和不良反应发生情况。结果治疗后,Ⅰ组总有效率92.5%,Ⅱ组总有效率82.5%,Ⅲ组总有效率77.5%。另外,Ⅰ组和Ⅱ组不良反应发生相对更少。整体比较,Ⅰ组治疗效果更佳,差异具有统计学意义(P<0.05)。结论在治疗输卵管妊娠中,采用甲氨蝶呤联合米非司酮的治疗方案效果更为显著,更值得临床推广。

Objective To explore the clinical effect of methotrexate in the treatment in tubal pregnancy.Methods The patients were divided into groupⅠ,groupⅡ and groupⅢ,each group respectively treatment with methotrexate joint mifepristone,methotrexate in different doses（50mg/m2and 100mg/m2）,then compared the treatment effects and adverse reaction.Results After treatment,the total efficient rate of groupⅠwas 92.5%,and groupⅡ was 82.5%,group Ⅲ was 77.5%.The adverse reaction case of groupⅠand groupⅡ were less,The treatmen of groupⅠwas better,there had a significant difference（P0.05）.Conclusion Methotrexate joint mifepristone treatment program is more effective in the treatment of tubal pregnancy,more worthy for clinical promotion.