瑞格列奈在治疗41例老年2型糖尿病中的疗效观察

The Efficacy of Repaglinide in the Rreatment of 41 Elderly Patients with Type 2 Diabetes

目的探讨瑞格列奈治疗老年2型糖尿病的临床疗效及安全性。方法选择41例老年2型糖尿病患者,给予瑞格列奈0.5～4mg,于每日餐前口服,每日3次,按进餐时服药,不进餐时不服药的原则。每周调整一次剂量到稳定剂量,最高剂量12mg,治疗12周。治疗期间保持饮食,生活规律、运动基本一致。对治疗前后测定空腹血糖(FBG)、餐后2h血糖(PBG2h)、糖化血红蛋白(HbA1c)及血胆固醇(TC)、血三酰甘油(TG)、及肝功(ALT)肾功(Cr BUN)、体质量指数(BMI)。结果治疗前空腹血糖(FBG)、餐后2h血糖(PBG2h)、糖化血红蛋白(HbA1c)分别为(8.4±1.0)mmol/L,(12.1±2.2)mmol/L,(9.30±1.98)%,治疗后分别为(6.70±0.93)mmol/L,(8.80±2.20)mmol/L,(6.8±1.07)%,治疗前后差异有统计学意义(P<0.05～0.01),无明显不良反应。结论瑞格列奈可迅速有效的控制血糖,不良反应轻微,是临床治疗老年2型糖尿病的理想药物。

Objective To investigate the repaglinide treatment of elderly patients with type 2 diabetes clinical efficacy and safety.Methods 41 cases of elderly patients with type 2 diabetes,given repaglinide 0.5 ~ 4mg,daily pre-dinner orally,3 times a day,according to meal medication,medication principle without meals.The dose to be adjusted once a week stable dose,the highest dose of 12mg,12 weeks of treatment.Diet during treatment,consistent patterns of life,sports.Before and after treatment,fasting blood glucose（FBG）,2 hours postprandial blood sugar（PBG2h）,glycosylated hemoglobin（HbA1c） and blood cholesterol（TC）,serum triglyceride（TG）,and liver function（ALT）,renal function（Cr BUN）,body mass index（BMI）.Results Before treatment,fasting blood glucose（FBG）,2-hour postprandial blood glucose（PBG2h）,glycosylated hemoglobin（HbA1c） were（8.4 ± 1.0） mmol/L（12.1 ± 2.2） mmol/L（9.30 ± 1.98）%,after treatment,respectively（6.70 ± 0.93） mmol/L（8.80 ± 2.20） mmol/L（6.8 ± 1.07）%,the difference was statistically significant（P0.05 to 0.01） before and after treatment,no significant adverse reactions.Conclusion Repaglinide can quickly Conclusion effective control of blood glucose,adverse reactions are mild,it is ideal for the clinical treatment of elderly patients with type 2 diabetes drug.