肝X受体与子痫前期关系的研究进展

Progress in the Relationship Between LXR and Preeclampsia

肝X受体(liver X receptor,LXR)是细胞核受体超家族的成员之一,也曾被称为孤儿受体。现已经明确LXR包括LXRα(NR1H3)和LXRβ(NR1H2)两种同源亚型。研究发现,LXR与甾醇调节元件结合蛋白(SREBP-1)、氧化修饰低密度脂蛋白(oxLDL)、一氧化氮(NO)、基质金属蛋白酶(MMPs)、Endoglin(CD105)、人绒毛膜促性腺激素(hCG)等存在联系,而这些因素又参与子痫前期的发病,证实了LXR与脂类的代谢、血管内皮的损伤、滋养细胞的增殖和侵袭等有关。因此LXR表达异常可能在子痫前期的发生发展中起重要作用。

The liver X receptor（LXR）is a member of the nuclear receptor superfamily,originally described as orphan receptor.It is now known LXR exists in two homologous isoforms： LXRα（NR1H3）and LXRβ（NR1H2）isoforms.Present studies have turn out that LXR has a relationship with sterol regulatory element-binding protein-1（SREBP-1）, oxidatively modified low density lipoprotein（oxLDL）,nitric oxide（NO）,matrix metalloproteinases（MMPs）,Endoglin（CD105）and human chorionic gonadotropin（hCG）which also participate in the pathogenesis of preeclampsia,demonstrating that LXR is associated with lipid metabolism,vascular endothelial injury,trophoblast cell proliferation and invasiveness as well.Therefore the abnormal expressivity of LXR may plays an important role in the development of preeclampsia.