可溶性血管内皮生长因子受体1与子痫前期的关系研究进展

Progress in Soluble Vascular Endothelial Growth Factor Receptor-1 and Preeclampsia

子痫前期是妊娠期特有疾病,以高血压和蛋白尿等为临床特征,影响母亲和新生儿的患病率和死亡率。尽管病因至今不明,但多数学者认为其发病与胎盘因子进入母体的血循环引起血管内皮的损伤有关。近年来发现,抗血管生成因子如内皮因子、可溶性血管内皮生长因子受体1(sFlt-1)以及胎盘生长因子都与子痫前期的发生有关。对sFlt-1分子结构及作用、调节因素、相关信号转导途径及其在子痫前期发病机制中的研究结果作一综述。

Pre-eclampsia is a complication of pregnancy characterized by hypertension and proteinuria that results in maternal and neonatal mortality and morbidity.Although the etiology remains unclear,it seems to be initiated by placental factors that enter the maternal circulation and may cause endothelial dysfunction.Recently,anti-angiogenic factors such as endoglin,the soluble form of vascular endothelial growth factor receptor（sFlt-1） as well as the placental growth factor have been found to be associated with the onset of pre-eclampsia.This review will summarize our current understanding of molecular structure of sFlt-1,signal pathways,with an emphasis on its role in the pathogenesis of preeclampsia and regulative factors.