子痫前期预测及治疗的研究进展

The Prediction and Treatment Research Progress of Preeclampsia

子痫前期是在妊娠中出现血压升高、蛋白尿等症状的一种疾病,子痫前期会对母婴健康产生严重影响,因此子痫前期的预测及治疗具有重要意义。综述尿液中的生物学标记物(胶原蛋白链、纤维蛋白原、尿调理蛋白)、血浆中生物学因子(fm-样酪氨酸激酶1、血管内皮生长因子、胎盘生长因子、激活素A、抑制素A、E-选择素)、临床危险因素(年龄、平均动脉压、体质量指数、子痫前期家族史)、血液动力学检查等对子痫前期的预测价值,丹参素、硫酸镁、降压药和普伐他汀等对子痫前期的治疗作用。

Preeclampsia is a disorder of pregnancy characterized by maternal hypertension and proteinuria.Preeclampsia play a serious role on maternal and child health,so the prediction and treatment of preeclampsia are significant.This article reviews the predictive value about biological markers of urine（collagen chains,fibrinogen,urinary regulating protein）,biological factors of plasma（FLT1,VEGFA,placental growth factors,activin A,inhibin A,E-selectin）,clinical risk factors（age,MAP,BMI,family history of preeclampsia）,hemodynamic check and the therapeutic effect of Danshensu salvianic acid,magnesium sulfate,antihypertensive,pravastatin.