羟乙基淀粉对心脏功能影响的临床观察

A clinical observation about cardiac function influenced by hydroxyethyl starch

目的:观察快速输注6%羟乙基淀粉(HES)130/0.4注射液对患者心脏功能的影响。方法:20例择期全麻平卧位手术患者,ASAⅠ～Ⅱ级,静脉快诱导插管待循环动力学平稳后,输注HES 15 mL/kg,30 mL/min。分别于输注前(T1)、HES输毕即刻(T2)、手术开始1 h(T3)、手术开始2 h(T4)、缝皮结束(T5)记录心功能参数。结果:平均动脉压(MAP)、心率(HR)和心肌加速度指数(ACI)在输注后各时点与输注前(T1)比较,未见明显改变(P>0.05);心输出量(CO)、每搏输出量(SV)、胸腔液体含量(TFC)在T2较T1升高(P<0.01);外周血管阻力(SVR)在T2较T1下降(P<0.01)。结论:以15 mL/kg,30 mL/min快速输注6%HES 130/0.4注射液对患者心脏功能无明显影响,临床安全可行。

Objective： To observe cardiac function when patients were infused with 6% hydroxyethyl starch （HES） 130/0.4 injection. Methods： 20 patients, ASA Ⅰ-Ⅱ level, who operated on supine surgery in general anesthesia, were rapidly infused with HES 15 mL/kg, 30 mL/min after intubation, parameters of cardiac function were respectively recorded when before the infusion（T1 ）, the end of HES infusion （T2）, after beginning the operation lh（T3）, after beginning the operation 2 h（T4） and the end of surgery（T5）. Results：MAP, HR, ACI were no significant differences in before（Tl） and after （T2） AHH （P 〉0.05）; CO, SV, TFC were higher at T2 than T1 （P 〈 0.05 or P 〈 0.01）; Compared with T1, SVR decreased at T2 （P〈 0.01 ）. Conclusion： Patients＇ cardiac function hasn＇t be influenced by this method which is safe and ef- fective.