摘要
目的:建立复方氢氯噻嗪片剂的溶出度考察方法。方法:考察在不同的溶出介质、转速下复方氢氯噻嗪片中的氢氯噻嗪和缬沙坦的溶出情况,筛选溶出参数。结果:确立了以1 000 mL PBS 6.8为溶出介质、桨法转速为50 r/min的溶出方法。结论:所建方法简便、准确、结果可靠,可用于药品制剂的质量控制。用该方法测得自制片剂与市售片剂溶出行为基本一致。
Objective： To establish a method for determining the dissolution of the compound hydrochlorothiazide tablets. Methods： The dissolution indexes were screened in different dissolution mediums and different rotation speeds, with the dissolution of hydrochloroth- iazide and valsartan. Results： The method of dissolution tests for the compound hydrochlorothiazide tablets were established with 1 000 mL PBS 6.8 as dissolution media and paddle rotation at the speed of 50 r/min. Conclusion：This method is simple and accurate,the re- sults are reliable and it could be used for quality control of pharmaceutical preparations. The cumulative dissolution percentage of the tablets tested by this way is similar to the in vitro dissolution behavior of the control preparations commercially available.
出处
《天津医科大学学报》
2012年第4期518-521,共4页
Journal of Tianjin Medical University
关键词
氢氯噻嗪
缬沙坦
片剂
溶出度
hydrochlorothiazide
valsartan
tablet
dissolution
