神经梅毒的实验诊断研究进展

Research progress of neurosyphilis experimental diagnosis

神经梅毒是梅毒螺旋体感染人体中枢神经系统出现的大脑、脑膜或脊髓损害的一组临床综合征,约10%的早期梅毒患者可发展为神经梅毒。近20年来,神经梅毒的发病率日益增加,其临床表现多种多样,早期可无症状或缺乏特异性症状,而抗生素的普遍使用使其临床症状和病程更不典型,高度敏感和特异的实验室指标尚有待进一步完善,误诊或漏诊可使神经梅毒进一步恶化成无法逆转的器质性病变。本文就神经梅毒的研究现状、临床诊断依据、实验诊断进展等方面进行总结性探讨,为其临床研究应用提供理论基础。

Neurosyphilis is a clinical syndrome of the brain, the meninges or spinal cord damaged owing to Treponema Pallidum infect the human central nervous system, about 10% of the patients with early syphilis may develop neurosyphilis. The past 20 years, the incidence of neurosyphilis growing, the clinical manifestations are diverse, early symptoms may be absent or lack of specific symptoms, and the widespread use of antibiotics make it less atypical about the clinical symptoms and course of the disease, a highly sensitive and specific experiments chamber indicators remains to be further improved, neurosyphilis can be further progression to irreversible organic disease due to misdiagnosis. In this paper, a summary of neurosyphilis research, clinical diagnosis, experimental diagnostic progress and so on will provide a theoretical basis for the clinical research applications.