抗HIV药物构效关系研究进展

Advances of structure-activity relationship on anti-HIV compounds

构效关系研究有助于提高药物研发的效率,是近年来抗HIV药物研究的一个热点。本文选择相关文献,综述了近年来抗HIV药物构效关系研究进展情况,对结果及所用研究方法进行总结。结果表明,相关文献为抗HIV药物的药效团及作用靶点等研究提供了大量的信息,构效关系研究的各种方法已经是抗HIV药物研究的重要工具。本文的结果对理解抗HIV药物的作用过程、耐药机制及新药的开发均有一定的意义。

Structure-activity relationship （SAR） study is helpful to the development of new drugs, which has been a hot point in the study of anti-HIV drugs. The advances of SAR of anti-HIV compounds is introduced to provide materials for the further study through collecting important literatures. The literatures give us great deal information of pharmacophore and targets, et al. SAR analysis has been a important technique in the study anti-HIV drugs. The results are instructive to the understanding of pharmaeody function process, resistance mechanism, and will be valuable to the development of new anti-HIV drugs.