51例生脉注射液致过敏反应文献分析

Analysis on 51 cases of anaphylactic reaction induced by shengmai injection

目的:分析生脉注射液所致过敏反应的特点,为临床合理用药提供参考。方法:采用回顾性研究方法,收集1989-2012年国内医药学术期刊报道的生脉注射液所致过敏反应病例,对患者基本资料、药物使用情况、过敏反应发生时间及其临床表现等进行归纳和分析。结果:静脉滴注生脉注射液所致过敏反应相关文献共38篇,有效病例51例。生脉注射液引起的不良反应未见明显的性别差异,在各年龄段均有分布,所致过敏反应主要表现为皮肤及附件损害20例(39.22%),过敏性休克19例(37.25%),胃肠道反应7例(13.73%)等。结论:生脉注射液引发的过敏反应与其主要成分的药理作用、制剂工艺等有关,应严格按照生脉注射液的适应证用药,对于连续用药的患者尤其应该加强关注。

Objective： To analyze the characteristics of anaphylactic reaction induced by shengmai injection, and provide reference for clinic drug use. Methods： We collected the ADR cases of anaphylactic reaction induced by shengmai injection reported on the domestic academic journals during 1989 - 2012, and analyzed the information of the patients, drug use, occurrence time and clinical manifestation of anaphylactie reactions included in the ADR cases retrospectively. Results： There were 51 cases of anaphylactic reaction induced by shengmai injection published in 38 papers, which had no obvious significance in gender and distributed in different age groups.The main clinical manifestation of the anaphylactic reactions induced by shengmai injection included 20 cases of skin and appendages disorder （39.22%）, 19 cases of anaphylactic shock （37.25%）, 7 cases of gastrointestinal reaction （13.73%）, and so on. Conclusion： The anaphylactic reaction induced by shengmai injection related to pharmacological effect of the components and preparation technology.Shengmai injection should be used rationally, especially when it was used continuously, more attention should be paid to.