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常态脑老化的神经病理改变与认知功能下降 被引量：7

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摘要 常态脑老化(NBA)并不出现阿尔茨海默病的痴呆症状,但是普遍出现不同程度的认知功能下降。神经元树突和棘突的结构性改变,以及脑白质中有髓神经纤维的大量减少,是引起常态脑老化认知功能改变的重要因素。此外,Aβ沉积和磷酸化tau蛋白也与常态脑老化的认知改变有关,但其影响认知的具体机制有所不同。对这些方面的深入研究有助于揭示增龄性认知障碍的原因,对脑老化相关疾病的研究和治疗具有重要意义。
作者 强静 耿媛 王铭维
机构地区 河北医科大学第一医院神经内科河北省脑老化与认知神经科学重点实验室
出处 《国际神经病学神经外科学杂志》 2012年第5期464-467,共4页 Journal of International Neurology and Neurosurgery
关键词 常态脑老化 认知功能下降 神经元结构 白质减少 淀粉样蛋白
分类号 R741 [医药卫生—神经病学与精神病学]
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参考文献31

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二级参考文献35

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二级引证文献63

国际神经病学神经外科学杂志
2012年 第5期

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