恶性肿瘤与非恶性肿瘤合并下肢深静脉血栓患者肺栓塞发生率的比较

Incidence of pulmonary embolism in cancer and non-cancer patients with deep venous thrombosis: a comparative study

目的：比较恶性肿瘤与非恶性肿瘤合并下肢深静脉血栓（DVT）患者肺栓塞（PE）发生率的差异。方法：回顾性分析近年收治的128例DVT患者的临床资料。将患者分为恶性肿瘤组（16例）与非恶性肿瘤组（112例）,分别比较两组住院和随访期间有症状PE的发生率。结果：住院期间（7~14 d）,恶性肿瘤组与非恶性肿瘤组有症状PE发生率分别为25.0%和2.7%,差异有统计学意义（P=0.005）。随访期间（6~60个月）,恶性肿瘤组失访2例,非恶性肿瘤组失访8例,两组发生PE各1例（8.3%vs.0.89%）且死亡,差异无统计学意义（P=0.185）。结论：恶性肿瘤合并下肢DVT的PE发生率增高。

Objective： To compare the incidence of pulmonary embolism （PE） in cancer and non-cancer patients with lower extremity deep vein thrombosis （DVT）. Methods： The clinical data of 128 patients with lower extremity DVT admitted in recent years were retrospectively analyzed. The patients were divided into cancer group （16 cases） and non-cancer group （112 cases）, and the incidences of symptomatic PE between the two groups during hospitalization and follow-up period were compared, respectively. Results： During hospitalization （7-14 d）, the incidence of symptomatic PE in cancer group and non-cancer group was 25.0% and 2.7% respectively, and the difference had statistical significance （P=0.005）. During follow-up period （6-60 months）, two cases in cancer group and 8 cases in non-cancer group were lost to follow-up, and one case in each group developed PE （8.3% vs. 0.89%） and died, and the difference had no statistical significance （P=0.185）. Conclusion： The incidence of PE is increased in cancer patients with lower extremity DVT.