Relationship between lower number of oocytes retrieved and clinical outcomes of in vitro fertilization-embryo transfer

Objective:To explore the clinical outcomes of the infertile women with retrieved oocytes less than or equal to 5 undergoing in vitro fertilization-embryo transfer（IVF-ET） or intracytoplasmic sperm injection（1CSI）. Methods:The clinical data of 216 embryo transfer cycles with retrieved oocytes less than or equal to 5 during the procedure of IVF/ICSI in Reproductive Medicine Center of the 105th Hospital of PLA from Jul.2008 to Dec.2011 were analyze retrospectively.All the patients were divided into group A（< 35 years）,group B（35-39 years） and group C（≥40 years） according to the ages,and 409 IVF/ICSI cycles with patients’ age less than 35 years old and 6-15 retrieved oocytes in the same period were served as controlled group.Then the patients≥35 years were subdivided into gonadotropin-releasing hormone agonist（GnRH-a） long protocol group,GnRH-a short group and GnRH antagonist group according to the protocols of controlled ovarian hyperstimulation（COH）.The clinical date and the outcomes were analyzed and compared among all groups. Results:There were significantly differences in clinical pregnancy rate（38.3%vs.19.4%） and early abortion rate（16.1%vs.50.0%） between group A and group C（P<0.05）,and there were no significant differences in clinical pregnancy rate（38.3%vs.41.6%）and early abortion rate（16.1%vs.10.0%） between group A and control group（P>0.05）.There were no significant differences in clinical pregnancy rates（29.01%vs.26.1%vs.25.9%） and early abortion rates（33.3%vs.33.3%vs.40.0%） among GnRH-a long protocol group,GnRH-a short group and GnRH antagonist group（P>0.05）. Conclusions:Relatively satisfactory clinical outcomes of IVF/ICSI would still be got for the patients <35 years with retrieved oocytes less than or equal to 5,but whatever COH protocols such as GnRH-a long protocol,GnRH-a short and GnRH antagonist could not improve the outcomes of IVF/ICSI for the patients aged≥35 with retrieved oocytes less than or equal to 5.

Objective： To explore the clinical outcomes of the infertile women with retrieved oocytes less than or equal to 5 undergoing in vitro fertilization-embryo transfer （IVF-ET） or intracytoplasmic sperm injection （ICSI）. Methods： The clinical data of 216 embryo transfer cycles with retrieved oocytes less than or equal to 5 during the procedure of IVF/ICSI in Reproductive Medicine Center of the 105th Hospital of PLA from Jul. 2008 to Dec. 2011 were analyze retrospectively. All the patients were divided into group A （〈 35 years）, group B （35-39 years） and group C （≥40 years） according to the ages, and 409 IVF/ICSI cycles with patients＂ age less than 35 years old and 6-15 retrieved oocytes in the same period were served as controlled group. Then the patients ≥ 35 years were subdivided into gonadotropin-releasing hormone agonist （GnRH-a） long protocol group, GnRH-a short group and GnRH antagonist group according to the protocols of controlled ovarian hyperstimulation （COH）. The clinical date and the outcomes were analyzed and compared among all groups. Results： There were significantly differences in clinical pregnancy rate（38.3 % vs. 19.4%） and early abortion rate （16.1% vs. 50.0%） between group A and group C （P〈0.05）, and there were no significant differences in clinical pregnancy rate（38.3% vs. 41.6%）and early abortion rate （16.1G vs. 10.0%） between group A and control group （P〉0.05）. There were no significant differences in clinical pregnancy rates （29.01% vs. 26.1% vs. 25.9%） and early abortion rates （33.3% vs. 33.3% vs. 40.0%） among GnRH-a long protocol group, GnRH-a short group and GnRH antagonist group （P〉0.05）. Conclusions： Relatively satisfactory clinical outcomes of IVF/ICSI would still be got for the patients 〈35 years with retrieved oocytes less than or equal to 5, but whatever COH protocols such as GnRH-a long protocol, GnRH-a short and GnRH antagonist could not improve the outcomes of IVF/ICSI for the patients aged ≥35 with retrieved oocytes less than or equal to 5.