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IL-2/LAK与放、化疗联合治疗晚期恶性肿瘤 被引量:1

IL-2/LAK cells combination radiotherapy and chemotherapy in the treatmemt of advanced cancer
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摘要 探讨IL-2/LAK细胞与放疗和/或化疗联合治疗晚期恶性肿瘤的价值。方法:本组共30例,其中单纯IL-2/LAK细胞治疗 5例(包括 2例TIL细胞胸腹腔灌注),IL-2/LAK细胞联合放疗18例(包括 1例动脉灌注),IL-2/LAK细胞联合化疗4例(包括1例动脉灌注),IL-2/LAK细胞联合放疗和化疗3例。结果:完全缓解率20.0%(6/30),总有效率 50.0%(15/30),其中单纯IL-2/LAK治疗有效率 20.0%(1/5),联合治疗有效率 56.0%(14/25)。2例 Kaposis’s肉瘤采用IL-2/LAK细胞联合放、化疗均达完全缓解,1例乳腺癌术后大量胸水用 TIL细胞+IL-2治疗达完全缓解。结论:IL-2/LAK细胞是有效的肿瘤过继性免疫疗法,和放、化疗联合应用可能有助于提高疗效。 Objective: To evaluate the results of IL-2/LAK cells combination radiotherapy and chemotherapy in the treatment of advanced cancer. Methods: 30 patients of advanced cancer were studied in this trial Of them, 5 patients treated by IL-2/LAK cells alone (2 of 5 patients received TIL cells), 18 patients received IL-2/LAK cells combination radiotherapy (1 of them received artery infusion), 4 patients recei-ved IL-2/ LAK cells combination chemotherapy (1 of them received artery infusion), and 3 patients received IL-2/LAK cells combination radiotherapy and chemotherapy. Results: The overall response rate was 50.0%, (15/30) with a complete response rate of 20.0% (1/5) in IL-2/LAK cells group only, and 56.0% (14/25 ) in combined group. Two patients with Kaposis's sarcoma achieved complete response. Conclusions: This result showed that IL-2/LAK cells for advanced carcinoma are effective, that IL-2/LAK cells combined with radiotherapy and (or) chemotherapy are conducive to good response rate.
出处 《新疆医科大学学报》 CAS 2000年第1期41-43,共3页 Journal of Xinjiang Medical University
关键词 IL-2/LAK细胞 恶性肿瘤 药物疗法 放射疗法 IL-2/LAK cells radiotherapy chemotherapy combined treatment malignant tumor
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  • 1谢琪,吴厚生,范行义,何球藻.I-UdR释放试验测定NK活性的比较研究[J]上海免疫学杂志,1987(06).
  • 2林兴华.Kaposi肉瘤研究进展[J]肿瘤,1984(03).

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  • 1汪建,赵洪进,范文汉,马惟力.鼻咽癌患者IL-2活性及IL-2R表达的测定[J].第三军医大学学报,1993,15(2):132-134. 被引量:1
  • 2刘孜,王国庆,李明众,刘隽悦.术中大剂量放疗对宫颈癌Ⅱ_b患者免疫系统的影响[J].癌变.畸变.突变,2005,17(4):247-249. 被引量:6
  • 3ChiKH,Myers JM,Chow KC,et al.Phase Ⅱ trial of systemic recombinant interleukin-2 in the treatment of refratory nasopharyngeal carcinoma[J].Oncology,2001,60(2):110 ~115
  • 4Pillai R,Balaram P,Bindu S,et al.Lymphocyte subset distribution after radiation therapy for cancer of the uterine cervix.Cancer,1991,67:2071 ~ 2078
  • 5Onsrud M,Grahm I,Gaudernack G,et al.Lymphoid cell distribution as prognostic factor in carcinomer of the uterine cervix.Acta Obstet Gynecol Scand,1992,71:135 ~ 139
  • 6Kikuchi Y,Iwano I,Kita T,et al.Changes of lymphocyte subsets in peripheral blood before and after operation of patients with advanced ovarian carcinoma.Cancer Res Clin Oncol,1990,116:283 ~ 287
  • 7Stewant GC.The influence of radiation on T-cell Int.T Raliat Biol,1988,55:77
  • 8Wilkins R.C,Wilkinson D,Maharaj H.P,et al.Differential apoptotic response to ionizing radiation in subpopulations of human white blood cells.Mutat.Res,2002,513:27 ~ 36
  • 9Moria M,Benotmanea bMA,Tironea I,et al.Transcriptional response to ionizing radiation in lymphocyte subsets.Cell.Mol.Life Sci.Res,2005,62:1489 ~ 1501
  • 10Dubray B,Bretoni C,Delic J,et al.In vitro radiation-induced apoptosis and early response to low-dose radiotherapy in non Hodgkin's lymphomas.Radiother Oncol,1998,46:185 ~ 191

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