异质生物网络的同步节律的实验研究

Experimental research on synchronous rhythms of biological network composed of heterogeneous cells

通过生物学实验研究了两个异质心肌细胞由独立到形成网络过程中的搏动节律随耦合强度的增加的动力学行为的变化.没有耦合时,两个细胞的搏动节律是独立的,没有同步的搏动.随着耦合强度的增加,网络内的两个细胞搏动节律的相位差的绝对值的平均值和最大值急剧降低,从非相位同步达到了相位同步,但没有达到完全同步.逐次对比两个细胞的搏动,非相位同步状态下只有部分搏动是同步的而其他搏动是不同步的,而相位同步状态下所有的搏动都是同步的.随着耦合强度的增加,非相位同步状态下的同步搏动次数增加,相位同步状态下的两细胞每次同步搏动的时间间隔降低但不为零.研究结果不仅给出了异质生物网络节律同步的实验例证,还获得了网络的节律从不同步到同步过程的动力学规律.

The evolution of the dynamic behaviors of beating rhythms from independent states to the formation of network is studied in biological experiment on two heterogeneous cells. The beating rhythms are independent and not synchronous when there is no coupling between two cells. With the enhancement of the coupling strength, the mean and maximum of absolute value of the phase difference drastically decrease in the beating rhythms of the two cells, from non-phase synchronization to phase synchronization, eventually not to full synchronization. Some of beatings become synchronous while others not synchronous for non-synchronization states while all beatings are synchronous for the phase synchronization state. With the increase of coupling strength, the times of synchronized beatings increases for the non-phase synchronization state, and time interval between the corresponding synchronous beatings of the two cells decreases to a low but non-zero value for the phase synchronization state. The results not only provide experimental demonstration of rhythm synchronization in a biological network, but also give changing regularity in the forming process of synchronous rhythm in the heterogeneous network.