男性与女性白塞病的对比研究

Comparative study on male and female patients with Behcet′s disease

目的 探讨不同性别的白塞病 (BD)的临床特点及预后。方法 对比分析 5 0例男性BD患者和 34例女性BD患者的临床表现。结果 与女性相比 ,男性以发热为首发症状者较多 (P <0 0 5 ) ,严重眼炎占眼受累的百分率明显高于女性 (P <0 0 5 ) ,男性更多地表现为针刺反应阳性及C 反应蛋白增高 (P分别小于 0 0 5和 0 0 1) ,而关节炎 /关节痛及OT试验或PPD试验的阳性率较低 (P均 <0 0 1)。皮肤表现在男性多为结节性红斑与毛囊炎共存 (P <0 0 5 ) ;而女性以单纯结节性红斑多见 (P <0 0 1)。对有眼受累的患者进行平均 49个月的随访 ,发现严重眼炎导致失明的比率在男性患者明显高于女性患者 (P <0 0 5 )。结论 男性患者往往病情较重 ,预后不佳。

Objective To investigate clinical characteristics and prognosis of male and female patients with BD.Method The clinical features of 50 male patients with BS (MBS) and 34 female patients with BS (FBS) were comparatively analyzed.Results As compared with FBS patients,the MBS patients were more likely to have fever as first symptom ( P <0 05),severe eye disease ( P <0 05),coexistence of folliculitis and erythema nodosum ( P <0 05),and higher positive rate of pathergy test as well as C reactive protein ( P <0 05 or 0 01).But their arthritis or arthralgia were less common and the positive rate of 1∶ 10 000 OT or PPD test were relatively lower in men ( P <0 01).Among the BS patients with eye involvement,A 49 month follow up showed that the rate of blindness owning to severe eye disease was significantly higher in men than that in women ( P <0 05).Conclusion Male sex seems to contribute to more severe disease and poor prognosis.