摘要
目的 :分析 bcr/ abl融合基因表达水平与α干扰素 (IFNα)治疗慢性粒细胞白血病 (CML )疗效及预后的关系。方法 :应用半定量 RT- PCR方法 ,分析 6例α干扰素治疗的 CML患者不同时期骨髓细胞 bcr/ abl融合基因表达水平。结果 :5例患者 bcr/ abl融合基因表达水平减低 ,临床获得持久完全血液学缓解。结论 :半定量 RT- PCR有助于α干扰素治疗 CML的疗效观察及预后判断。
Objective: To study the relation between the expression of bcr/abl gene and the effects of interferon α in treatment of CML. Methods: By using semi quantitative RT PCR, bone marrow cells from 6 CML(chronic phase) patients were analyzed for the expression of fusion gene at pre treatment and during intervals after treatment with interferon α. Results:Five patients with decreasing levels of bcr/abl mRNA expression were in complete hematological remission. Conclusion: The semi quantitative RT PCR may be used to evaluate the prognosis of CML with interferon α treatment.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
2000年第3期236-238,共3页
Academic Journal of Second Military Medical University
基金
国家自然科学基金!( 3 9970 70 9)
关键词
干扰素Α
粒细胞
药物疗法
慢性白血病
CML
interferon alpha
chronic myelogenous leukemia
fusion genes, bcr/abl