摘要
目的 :探讨大肠癌组织中 β-连环蛋白 (β- catenin)的表达是否与浸润、转移相关。方法 :应用免疫组化方法检测 44例大肠癌患者原发灶、临近非肿瘤大肠粘膜组织中的 β-连环蛋白的表达情况。结果 :正常大肠粘膜中 β-连环蛋白强烈表达 ,而其在大肠癌原发灶中的染色特征发生改变 ,表达程度明显弱于临近非肿瘤大肠粘膜 ,且与大肠癌的生长方式、分化程度、淋巴结转移、Dukes分期等临床病理因素密切相关。 结论 :β-连环蛋白的表达水平可以作为预测大肠癌转移潜能的一个参考指标。
Objective: To determine whether the expression level of β catenin correlates with the invasion and metastasis of human colorectal cancer. Methods: Using immunohistochemical staining technique, expression of β catenin were investigated in different tissues from 44 specimens of colorectal cancer, including the primary tumor and normal colorectal mucosa nearby the tumor. Results: Normal colorectal mucosa strongly expressed β catenin. However, in the primary cancer, expression of β catenin not only distributed disorderly but also was frequently reduced. The level of β catenin expression was closely related with the growth pattern, cellular differentiation, lymphatic metastases and Dukes stage. Conclusion: The down regulation of β catenin expression might be a predictor indicating the metastatic potential of colorectal cancer.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
2000年第3期239-241,共3页
Academic Journal of Second Military Medical University