未成年人尿钙与肌酐比值测定及其意义

Measurement of the urinary calcium to creatinine ratios in non-adult and its significance

目的 :探讨未成年人尿钙 /肌酐 (Ca2 + / Cr)比值的分布特征、影响因素及其对高钙尿症的诊断价值。 方法 :对上海1833例 3～ 18岁未成年人行尿钙、尿 Cr普查测定 ,15 4例行 2 4h尿钙定量分析。结果 :尿 Ca2 + / Cr值呈偏态分布 ,其第 95百分位数为 0 .2 85 ,与性别无关 ,但不同年龄和地区之间略有差异。对高钙尿症诊断的敏感性为 98.9% ,特异性为 5 9.0 %。结论 :尿 Ca2 + / Cr测定是一简便而实用的高钙尿症筛选试验 ,其标准应考虑受检对象的年龄和所在地区的影响。

Objective: To investigate the frequency distribution and influencing factors of urinary calcium to creatinine ratios (Ca 2+ /Cr) and to evaluate its value on diagnosis of hypercalciuria. Methods: Urinary calcium and creatinine were measured in 1 833 non adult aged 3 to 18 and 24 hour urine calcium excretion were quantified in 154 selected subjects. Results: The frequency distribution of Ca 2+ /Cr was shown skews and 95 percentile of Ca 2+ /Cr was 0.285. The value of Ca 2+ /Cr was related to age and district where the subjects lived, but not to sex. The sensitivity and specificity of the Ca 2+ /Cr test for hypercalciuria were 98.9% and 59.0%, respectively. Conclusion:A random urine Ca 2+ /Cr could serve as a simple and useful screening test for hypercalciuria.