准分子激光屈光性角膜切削术后角膜上皮愈合的影响因素

The affecting factors of corneal epithelial healing after photorefractive keratectomy

目的 探讨年龄、性别、绷带式隐形眼镜配戴、术后局部使用不同药物及手术切削深度诸因素对PRK术后角膜上皮愈合的影响。方法 对 2 5 8例实施PRK术病人 (393只眼 )进行前瞻、随机、双盲、设立安慰剂对照的临床研究。结果 不同年龄、性别、术后配戴隐形眼镜及手术切削深度诸因素对角膜上皮愈合时间无显著性差别 (P >0 0 5 )。术后使用双氯灭痛滴眼液、透明质酸钠及安慰剂组角膜上皮愈合的时间分别是 :3 78天± 1 37天、2 86天± 1 44天、3 31天± 1 5 0天 (P <0 0 5 )。结论 年龄、性别、术后配戴隐形眼镜以及手术切削深度对PRK术后角膜上皮愈合不构成影响 ,而双氯灭痛可延长角膜上皮愈合 ,透明质酸钠可促进角膜上皮的修复。

ObjectiveTo explore the affecting factors of corneal epithelial healing after photorefractive keratectomy(PRK).MethodsA prospective,randomized,double masked,placebo control clinical study was conducted in 258 consecutive patients(393 eyes) undergone PRK.General information including age,sex,photoablative depth were recorded before or after PRK.The bandage lens wearing,diclofanac,sodium hyaluronic or BSS eye drops were used by randomized,double masked methods.Corneal epithelial healing were evaluated by slit lamp after PRK.ResultsThe healing time of corneal epithelia in age,sex,bandage lens and photoablative depth was showed no difference( P >0 05).The healing time of diclofanac,sodium hyaluronic or BSS eye drops was 3 78±1 37?d,2 86±1 44?d,3 31±1 50?d,respectively ( P <0 05).ConclusionThe age,sex,bandage lens and photoablative depth have no effect on corneal epithelial healing after PRK.Diclofanac might delay corneal epithelial healing,and sodium hyaluronic can accelerate it.