浙江省发热伴血小板减少综合征病例临床与流行病学特征分析

Analysis on clinical and epidemiological characteristics of severe fever with thrombocytopenia syndrome in Zhejiang province

目的分析发热伴血小板减少综合征病例临床与流行病学特征,为进一步研究提供线索。方法采用流行病学个案调查与描述性分析方法,收集发热伴血小板减少综合征确诊与疑似病例发病、诊治、检测与流行病学史等资料,分析病例临床与流行病学特征。结果浙江省6类地形中有3类存在发热伴血小板减少综合征疫情,病例以丘陵山区50岁以上人群为主(87.50%),6～7月为发病高峰(65.00%)。所有病例均有发热,体温最低37.6℃,最高40.6℃,平均39.2℃,且发热为主要首发症状。大部分病例有畏寒(67.50%)、乏力(67.50%)、食欲减退(52.50%)等非特异性症状。病例临床表现为发热伴白细胞和血小板减少,白细胞和血小板进行性减少可持续至发病后14～15d,且血小板进行性减少持续时间更长,未发现人传人现象。结论浙江省发热伴血小板减少综合征病例临床与流行病学特征与其他省份比较存在差异,有待于进一步研究解决。

Objective To understand the clinical and epidemiological characteristics of severe fever with thrombocytopenia syndrome（SFTS）and to provide clues for further study.Methods A descriptive epidemiological method combined with individual case investigation was to analyze the data on epidemiology,diagnosis and treatment collected from clinically diagnosed as well as suspicious patients with severe fever and thrombocytopenia syndrome.Results Out of 6 topography,3 were found to be endemic with SFTS.Most cases were 50 and over residing in hilly regions（87.50%）and 65.00% of patients were reported from June to July.They all experienced fever with the body temperature ranging from 37.6℃ to 40.6℃,which was the major onset symptom.Meanwhile,most patients also experienced chill,fatigue,anorexia and other non-specific symptoms.The major clinical symptoms were fever,thrombocytopenia and leucocytopenia which could last 14 or 15 days or even longer for thrombocytopenia.Person to person transmission was not found.Conclusions There are differences in clinical and epidemiological characteristics of severe fever with thrombocytopenia syndrome in Zhejiang compared with other provinces.Further study needs to be done.